The simple answer is yes, but the world isn't a simple place, so: it depends.
I majored in Creative Writing as an undergrad and couldn't find a job afterwards that would let me pay the rent.
"Well," most people would say, "Duh."
And many of them certainly have.
But what if I had majored in medicine or science or computers or business? Not only am I disiniterested, but they do not employ my strengths as a person. Yes, computers and medicine are where some of the best jobs are right now, but would you want a slow computer repairman? Would you want a nurse who got nervous around needles and blood and open wounds?
In college I carpooled with a guy who liked writing but majored in business. He complained about his business classes all the time, and I always wondered if he was going to complain about having a business as much as he was complaining about learning about business.
So what other major options are there, besides history, philosophy, art, or political science -- all of which are as useless or almost as useless as creative writing? Though Penelope Trunk and I may disagree a bit here on doing what you love, we come up with a similar conclusion.
What I wish I had figured out is how to take what I'm good at (reading, writing, humanities/arts) and choose a major that was related to that but would be more useful in the job market -- like public relations. I have not always wanted to be a PR rep, but PR reps still write and talk to people. The position employs skills that are similar to those needed by journalists, writers, and professors. Working for a PR firm may not be my dream job, but it's something that I would enjoy and be good at.
That's my suggestion -- don't go into a field that you aren't interested in, that you're not good at, just because you can't make a living painting. Do major in what you love. Then maybe try finding an alternate job or career that uses those talents that you enjoy using.
Update: Liberal Arts Graduates Create Careers.